XENOBIOTIC METABOLISM IN IDIOPATHIC PARKINSONS-DISEASE IN NIGERIAN AFRICANS

Authors
IGBOKWE E OGUNNIYI AO OSUNTOKUN BO
Citation
E. Igbokwe et al., XENOBIOTIC METABOLISM IN IDIOPATHIC PARKINSONS-DISEASE IN NIGERIAN AFRICANS, East African medical journal, 70(12), 1993, pp. 807-809
Citations number
16
Categorie Soggetti
Medicine, General & Internal
Journal title
East African medical journal → ACNP
ISSN journal
0012835X
Volume
70
Issue
12
Year of publication
1993
Pages
807 - 809
Database
ISI
SICI code
0012-835X(1993)70:12<807:XMIIPI>2.0.ZU;2-R
Abstract
The acetylator phenotype using sulphadimidine as a probe drug was stud ied in 20 idiopathic Parkinson's disease (IPD) patients and 21 control subjects. 10(50%) of the IPD patients belonged to the slow acetylator phenotype but this did not differ significantly from the proportion 7 (33%) of control subjects who were slow acetylators. The result does not suggest a role for acetylation in the aetiopathogenesis of IPD in Nigerian African.