2 DIFFERENT ISOFORMS OF DESMOCOLLIN ARE RECOGNIZED BY AUTOANTIBODIES IN VARIOUS TYPES OF PEMPHIGUS

We have previously reported that, in addition to well-known pemphigus antigens (desmoglein and pemphigus vulgaris antigen), desmocollin (Dsc ), another desmosomal cadherin, is recognized by certain pemphigus ser a. Furthermore, we noticed that two Dsc species with a slightly differ ent relative molecular weight were recognized by various pemphigus ser a. This difference may contribute to the different clinicopathological features between the subcorneal pustular dermatosis type and the intr aepidermal neutrophilic IgA dermatosis type of intercellular IgA vesic ulopustular dermatosis.