SINGLET OXYGEN AND SUPEROXIDE CHARACTERISTICS OF A SERIES OF NOVEL ASYMMETRIC PHOTOSENSITIZERS

Authors
HAYLETT AK MCNAIR FI MCGARVEY D DODD NJF FORBES E TRUSCOTT TG MOORE JV
Citation
Ak. Haylett et al., SINGLET OXYGEN AND SUPEROXIDE CHARACTERISTICS OF A SERIES OF NOVEL ASYMMETRIC PHOTOSENSITIZERS, Cancer letters, 112(2), 1997, pp. 233-238
Citations number
30
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
112
Issue
2
Year of publication
1997
Pages
233 - 238
Database
ISI
SICI code
0304-3835(1997)112:2<233:SOASCO>2.0.ZU;2-2
Abstract
The singlet oxygen quantum yields and superoxide quantum yields for a series of novel compounds based on an asymmetrical protoporphyrin mole cule have been examined. Electron spin resonance was used to measure s uperoxide yield and time resolved luminescence for singlet oxygen. A c omparison between these results and previously published cell survival data was carried out. A broad association was found between singlet o xygen quantum yield and clonogenic cell kill. (C) 1997 Elsevier Scienc e Ireland Ltd.