DECREASED EXPRESSION OF HLA CLASS-I ON OCULAR MELANOMA-CELLS FOLLOWING IN-VITRO PHOTODYNAMIC THERAPY

Citation
Djr. Blom et al., DECREASED EXPRESSION OF HLA CLASS-I ON OCULAR MELANOMA-CELLS FOLLOWING IN-VITRO PHOTODYNAMIC THERAPY, Cancer letters, 112(2), 1997, pp. 239-243
Citations number
15
Categorie Soggetti
Oncology
Journal title
ISSN journal
03043835
Volume
112
Issue
2
Year of publication
1997
Pages
239 - 243
Database
ISI
SICI code
0304-3835(1997)112:2<239:DEOHCO>2.0.ZU;2-N
Abstract
Our objective was to investigate whether photodynamic therapy (PDT) in fluences the expression of HLA Class I and beta 2-microglobulin molecu les on cultured uveal melanoma cells. Uveal melanoma cells were incuba ted with hematoporphyrin esters (HPE) and illuminated using red light. HLA expression on cells was determined by flowcytometry. PDT treatmen t induced an immediate reduction in expression of HLA Class I and beta 2-microglobulin, followed by a transient increase in expression after 2 h. Normalization occurred after 6 h. Treatment of ocular melanoma c ells with PDT temporally alters the expression of HLA Class I and beta 2-microglobulin, which may affect anti-tumor-immune responses. (C) 19 97 Elsevier Science Ireland Ltd.