Completed Forms containing the Edinburgh handedness inventory were rec
eived from 77 women exposed to diethylstilbestrol (DES) in utero. Late
rality scores (LSs; range: - 100 to + 100) were calculated for each re
spondent based on the handedness inventory and were compared with LSs
from 514 female controls. The handedness distribution in the DES daugh
ters was significantly shifted away from strong righthandedness compar
ed with the handedness distribution in the controls (chi-square = 22.0
, P<0.0001). Possible explanations For the association between handedn
ess and DES exposure are presented, and aspects of handedness measurem
ent are discussed.