INHIBITORY EFFECT ON ANTI-LIPID-IV ANTISE RUM BINDING-ACTIVITY OF VARIOUS SYNTHETIC OLIGOSACCHARIDES

The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzym e linked immunosorbent assay). Compound 8, containing an epitope GlcA- 4Mebeta1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing e nd disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups wa s synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each an tiserum.