CHLOROQUINE EXCRETION IN SEMEN FOLLOWING ANTIMALARIAL-DRUG ADMINISTRATION

The study described here was carried out to establish whether or not c hloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorime tric method before and after taking a total dose of 1.500 mg chloroqui ne base corresponding to the accepted dosage of the drug in malarial c hemotherapy. Mean pre- and post-drug administration levels of 0.7 +/- 0.2 muM and 5.7 +/- 0.6 muM were obtained respectively, indicating a s ignificant excretion of chloroquine in semen.