Despite decades of aggressive research into the cause and cure of mult
iple sclerosis (MS), a direct management strategy remains lacking. As
research continues, patients who strive for an improved quality of lif
e may attain it through the improved management of symptoms. Symptoms
occur in MS as a consequence of loss of myelin (primary symptoms), as
the result of primary symptoms (secondary symptoms), and because of ps
ychological dysfunction associated with MS (tertiary symptoms). This p
aper emphasizes the recent developments in the management of primary s
ymptoms including visual loss, weakness, spasticity, urinary and sexua
l dysfunction, and fatigue. The adjective multiple emphasizes the nume
rous potential symptoms of MS. It is through their management that peo
ple with MS may lead happier, more productive lives until a cause and
cure are found.