Constrictive pericarditis is a unique disease entity characterized by
a rigid nondistended pericardium associated with hemodynamic impairmen
t of diastolic expansion of the ventricles. A patient, who has typical
findings consistent with constrictive pericarditis, has shown markedl
y abnormal ischemic changes on electrocardiography on exercise testing
but completely normal coronary anatomy. This finding, which has not b
een described in the literature, would suggest that the diastolic impa
irment of ventricular expansion could be another mechanism of false-po
sitive exercise testing. The importance of pericardium should be empha
sized in pathophysiology of ischemic electrocardiographic changes duri
ng the exercise.