PHARMACODYNAMIC EFFECTS OF SUBINHIBITORY CONCENTRATIONS OF IMIPENEM ON PSEUDOMONAS-AERUGINOSA IN AN IN-VITRO DYNAMIC-MODEL

Authors
MAGGIOLO F TARAS A FRONTESPEZI S LEGNANI MC SILANOS MA PRAVETTONI G SUTER F
Citation
F. Maggiolo et al., PHARMACODYNAMIC EFFECTS OF SUBINHIBITORY CONCENTRATIONS OF IMIPENEM ON PSEUDOMONAS-AERUGINOSA IN AN IN-VITRO DYNAMIC-MODEL, Antimicrobial agents and chemotherapy, 38(6), 1994, pp. 1416-1418
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
6
Year of publication
1994
Pages
1416 - 1418
Database
ISI
SICI code
0066-4804(1994)38:6<1416:PEOSCO>2.0.ZU;2-6
Abstract
The postantibiotic effect (PAE), sub-MIC effect (SME), and postantibio tic sub-MIC effect (PASME) of imipenem on Pseudomonas aeruginosa were investigated with an in vitro dynamic model reproducing in vivo elimin ation kinetics of the antibiotic. The PASMEs were constantly longer th an the corresponding SMEs, but differences between them sere not stati stically significant. Both PASMEs and SMEs were initially bactericidal and were significantly longer than PAEs. The mean values of both PASM Es and SMEs were over 12 h. SMEs appear to be more relevant for the ba cterial growth kinetics than PAEs.