COMPARATIVE IN-VITRO ACTIVITIES OF NEW QUINOLONES AGAINST CORYNEFORM BACTERIA

The in vitro activities of eight quinolones against 115 coryneform bac teria (20 Corynebacterium jeikeium, 15 Corynebacterium minutissimum, 1 5 Corynebacterium striatum, 25 Corynebacterium urealyticum, 10 Coryneb acterium xerosis, 10 Corynebacterium group ANF-1, 10 Corynebacterium g roup 12, and 10 Listeria monocytogenes) were determined. The MICs of c iprofloxacin, ofloxacin, and sparfloxacin for 90% of C. jeikeuim, C. u realyticum, and C. xerosis isolates tested were >16 mu g/ml. Those of BAY Y 3118 and clinafloxacin against these species were 0.5 and 1 to 2 mu g/ml, respectively. The MICs for 90% of all 115 strains tested wer e 0.5 mu g/ml for BAY Y 3118, 1 mu g/ml for clinafloxacin, 2 mu g/ml f or E-5068, 4 mu g/ml for E-5065, and >16 mu g/ml for ciprofloxacin, of loxacin, sparfloxacin, and E-4868.