Mv. Borobio et al., COMPARATIVE ACTIVITIES OF 8 QUINOLONES AGAINST MEMBERS OF THE BACTEROIDES-FRAGILIS GROUP, Antimicrobial agents and chemotherapy, 38(6), 1994, pp. 1442-1445
The in vitro activities of five new quinolones (clinafloxacin [CI-960
or PD-127391], BAY Y 3118, E-4868, E-5065, and E-5068) against 100 Bac
teroides fragilis group bacterial isolates were compared with those of
ciprofloxacin, ofloxacin, and sparfloxacin. Overall, E-5068 was the m
ost active in vitro (MIC for 90% of isolates tested [MIC(90)], 0.25 mu
g/ml); this was followed by clinafloxacin and BAY Y 3118 (MIC(90), 0.
5 mu g/ml). Ciprofloxacin, sparfloxacin, and ofloxacin were the least
active (MIC(90)s, 64, 16, and 16 mu g/ml, respectively). B. fragilis a
nd Bacteroides caccae were more susceptible than the other members of
the B. fragilis group to all of the quinolones tested.