A PECULIAR DISTRIBUTION OF PEROXISOMES IN A PATIENT WITH NODULAR REGENERATIVE HYPERPLASIA OF THE LIVER

In a patient with nodular regenerative hyperplasia of the liver, perox isomes formed rows along the sinusoidal surface of the parenchymal cel ls, in contrast to their homogeneous distribution in the normal liver. In some cells, peroxisomes had a perinuclear configuration. Morphomet ric data were compared to those of seven control livers and revealed n ormal values of the peroxisomal diameter, axial ratio, volume density, numerical density and surface density. Peroxisomes with cytoplasmic i nvaginations, protrusions and gastruloid cisternae were rare. Angular profiles were frequently found. The peculiar distribution of the perox isomes may be linked to the deficient blood supply to the liver in nod ular regenerative hyperplasia. (C) Journal of Hepatology.