We report multifocal choroiditis associated with progressive subretina
l fibrosis in 2 healthy, young, myopic women. One of the patients show
ed bilateral choroiditis but unilateral subretinal fibrosis. The other
had myopic anisometropia, and choroidal lesions developed only in the
more myopic eye. Systemic evaluation was noncontributory. We suggest
that local factors, and unknown hormonal irregularities in young women
, may play a role in the development of this rare disorder.