COMPARATIVE-STUDY OF IMMUNOMODULATORY PROPERTIES OF MURAMYL PEPTIDES ON IMMUNE-SYSTEM CELLS OF YOUNG AND OLD MICE

Authors
DOZMOROV IM KUZIN II LUTSAN NI LUTSENKO GV PROKHOROVA AL SAPOZHNIKOV AM ANDRONOVA TM IVANOV VT
Citation
Im. Dozmorov et al., COMPARATIVE-STUDY OF IMMUNOMODULATORY PROPERTIES OF MURAMYL PEPTIDES ON IMMUNE-SYSTEM CELLS OF YOUNG AND OLD MICE, Immunopharmacology and immunotoxicology, 16(2), 1994, pp. 149-163
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Immunopharmacology and immunotoxicology → ACNP
ISSN journal
08923973
Volume
16
Issue
2
Year of publication
1994
Pages
149 - 163
Database
ISI
SICI code
0892-3973(1994)16:2<149:COIPOM>2.0.ZU;2-5
Abstract
The immunomodulatory effects of two synthetic muramyl peptides (MP): m uramyl dipeptide and glucosaminyl- muramyl dipeptide have been compare d. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: in creasing of T helper precursors frequency and IL-1 production by macro phages. In the latter both MPs acted as correctors, recovering the dec reased IL-1 production by old mice macrophages to young control level.