THE NONPEPTIDE NEUROTENSIN ANTAGONIST, SR-48692 USED AS A TOOL TO REVEAL PUTATIVE NEUROTENSIN RECEPTOR SUBTYPES

Authors
DUBUC I COSTENTIN J TERRANOVA JP BARNOUIN MC SOUBRIE P LEFUR G ROSTENE W KITABGI P
Citation
I. Dubuc et al., THE NONPEPTIDE NEUROTENSIN ANTAGONIST, SR-48692 USED AS A TOOL TO REVEAL PUTATIVE NEUROTENSIN RECEPTOR SUBTYPES, British Journal of Pharmacology, 112(2), 1994, pp. 352-354
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
112
Issue
2
Year of publication
1994
Pages
352 - 354
Database
ISI
SICI code
0007-1188(1994)112:2<352:TNNASU>2.0.ZU;2-H
Abstract
The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently sho wn to inhibit NT binding to the cloned rat and human NT receptor and t o antagonize NT effects in a variety of in vitro and in vivo assays. H ere, we show that, in contrast to its antagonistic action on NT-induce d hypomotility in the rat, SR 48692 failed to antagonize NT-induced hy pothermia and analgesia in the mouse and rat. We suggest that these ef fects might be mediated through a subtype of SR 48692-insensitive NT r eceptor.