PREPARATION OF TRISULFIDE DERIVATIVES OF CYSTINE AND THEIR FORMATION AS BY-PRODUCTS DURING PEPTIDE-SYNTHESIS

Authors
PARMENTIER B MOUTIEZ M TARTAR A SERGHERAERT C
Citation
B. Parmentier et al., PREPARATION OF TRISULFIDE DERIVATIVES OF CYSTINE AND THEIR FORMATION AS BY-PRODUCTS DURING PEPTIDE-SYNTHESIS, Tetrahedron letters, 35(21), 1994, pp. 3531-3534
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
21
Year of publication
1994
Pages
3531 - 3534
Database
ISI
SICI code
0040-4039(1994)35:21<3531:POTDOC>2.0.ZU;2-8
Abstract
The formation of a trisulfide derivative is observed when di-NH2-prote cted cystine, is used during peptide synthesis. This side reaction occ urs during the coupling step with several coupling reagents. A conveni ent method for the preparation of these derivatives in mild conditions is described