A NEW REDUCTIVE ACIDOLYSIS FINAL DEPROTECTION STRATEGY IN SOLID-PHASEPEPTIDE-SYNTHESIS - USE OF A NEW SAFETY CATCH LINKER

Authors
KISO Y FUKUI T TANAKA S KIMURA T AKAJI K
Citation
Y. Kiso et al., A NEW REDUCTIVE ACIDOLYSIS FINAL DEPROTECTION STRATEGY IN SOLID-PHASEPEPTIDE-SYNTHESIS - USE OF A NEW SAFETY CATCH LINKER, Tetrahedron letters, 35(21), 1994, pp. 3571-3574
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
21
Year of publication
1994
Pages
3571 - 3574
Database
ISI
SICI code
0040-4039(1994)35:21<3571:ANRAFD>2.0.ZU;2-V
Abstract
A new reductive acidolysis final deprotection strategy in solid phase peptide synthesis was developed using a new safety-catch linker; this new strategy was based on a two-dimensional protection scheme employin g acid-labile temporary and acid-stable but reductive acidolysis-cleav able semipermanent protecting groups.