REFINED LOCALIZATION OF THE BRANCHIOOTORENAL SYNDROME GENE BY LINKAGEAND HAPLOTYPE ANALYSIS

Authors
NI L WAGNER MJ KIMBERLING WJ PEMBREY ME GRUNDFAST KM KUMAR S DAIGER SP WELLS DE JOHNSON K SMITH RJH
Citation
L. Ni et al., REFINED LOCALIZATION OF THE BRANCHIOOTORENAL SYNDROME GENE BY LINKAGEAND HAPLOTYPE ANALYSIS, American journal of medical genetics, 51(2), 1994, pp. 176-184
Citations number
31
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of medical genetics → ACNP
ISSN journal
01487299
Volume
51
Issue
2
Year of publication
1994
Pages
176 - 184
Database
ISI
SICI code
0148-7299(1994)51:2<176:RLOTBS>2.0.ZU;2-S
Abstract
Branchiootorenal (BOR) syndrome is a common autosomal dominant form of hearing impairment previously mapped to 8q. This report refines the l ocalization of the BOR syndrome gene by haplotype analysis to the inte rval flanked by markers D8S553 and D8S286. By multipoint linkage analy sis, the disease locus most likely is flanked by markers D8S530 and D8 S279. (C) 1994 Wiley-Liss, Inc.