TUMORIGENICITY OF A COMBINATION OF PSORIASIS THERAPIES

Authors
PHILLIPS DH ALLDRICK AJ
Citation
Dh. Phillips et Aj. Alldrick, TUMORIGENICITY OF A COMBINATION OF PSORIASIS THERAPIES, British Journal of Cancer, 69(6), 1994, pp. 1043-1045
Citations number
13
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
69
Issue
6
Year of publication
1994
Pages
1043 - 1045
Database
ISI
SICI code
0007-0920(1994)69:6<1043:TOACOP>2.0.ZU;2-2
Abstract
Coal tar, a tumour initiator, and dithranol, a tumour promoter, are us ed in the treatment of psoriasis. Topical treatment of mice with pharm aceutical formulations of these two agents, at therapeutic doses, indu ced skin papillomas in a classical two-stage carcinogenesis protocol, while treatment with either agent alone did not. This finding has impl ications for the use of both agents in combination in the treatment of psoriasis.