COCAINE-INDUCED AGITATED DELIRIUM, FORCEFUL STRUGGLE, AND MINOR HEAD-INJURY - A FURTHER DEFINITION OF SUDDEN-DEATH DURING RESTRAINT

Four cases from the Philadelphia Medical Examiner's Office are present ed and the literature is reviewed to define further the syndrome of su dden death occurring during cocaine-induced-agitated delirium and stru ggle during restraint in individuals who also sustain minor head injur y. The mechanism of death involves a terminal arrhythmia, most likely due to sympathetic sensitization of the myocardium by cocaine and the stress of struggle sometimes juxtaposed upon the stratum of minimal na tural disease. In the cases described, the head injury in itself was i nsufficient to be a cause of death. Recognition of the role of the pha rmacologic effect of cocaine and the lethal effects of its use in this setting is crucial.