HPLC-SEPARATION OF SOME MANDELIC-ACID EST ER DERIVATIVES USING ALPHA(1)-ACID GLYCOPROTEIN (AGP)

Authors
JIRA T EPPERLEIN U BEYRICH T
Citation
T. Jira et al., HPLC-SEPARATION OF SOME MANDELIC-ACID EST ER DERIVATIVES USING ALPHA(1)-ACID GLYCOPROTEIN (AGP), Archiv der pharmazie, 327(5), 1994, pp. 283-286
Citations number
7
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
5
Year of publication
1994
Pages
283 - 286
Database
ISI
SICI code
0365-6233(1994)327:5<283:HOSMEE>2.0.ZU;2-I
Abstract
Investigations on direct HPLC-resolution of the racemates of mandelic acid ester and phenylacetic acid ester derivatives using alpha1-acid g lycoprotein on silica (AGP) as the chiral stationary phase are describ ed. The influence of various uncharged and charged modifiers (2-propan ol, octanoic acid, N,N-dimethyloctylamine) in the mobile phase separat ely and in combination by variation of the pH-value was studied.