APPROACH TO DETECT SUBSTRATES SUITABLE TO MEASURE THE COUMARIN 7-HYDROXYLASE (CYP 2A-5) - STRUCTURE-ACTIVITY-RELATIONSHIPS

Authors
TEGTMEIER M LEGRUM W
Citation
M. Tegtmeier et W. Legrum, APPROACH TO DETECT SUBSTRATES SUITABLE TO MEASURE THE COUMARIN 7-HYDROXYLASE (CYP 2A-5) - STRUCTURE-ACTIVITY-RELATIONSHIPS, Archiv der pharmazie, 327(5), 1994, pp. 299-302
Citations number
30
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
5
Year of publication
1994
Pages
299 - 302
Database
ISI
SICI code
0365-6233(1994)327:5<299:ATDSST>2.0.ZU;2-D
Abstract
Besides coumarin, which up to now has remained the most selective subs trate for the coumarin 7-hydroxylase (Coh), 7-ethoxycoumarin, quinolin e, 4-methylcoumarin, 7-ethoxy-4-methylcoumarin, 7-ethoxy-4-ethylcoumar in, and psoralen are suitable for this enzyme. - The quantification of the suitability of a substrate to selectively measure the coumarin 7- hydroxylase is achieved by a graphic method. - Requirements for servin g as a substrate of the Coh are bicyclic ring systems with an electron rich moiety.