METABOLISM OF SUBSTANCE-P AND NEUROKININ-A BY HUMAN VASCULAR ENDOTHELIUM AND SMOOTH-MUSCLE

Authors
WANG LH SADOUN E STEPHENS RE WARD PE
Citation
Lh. Wang et al., METABOLISM OF SUBSTANCE-P AND NEUROKININ-A BY HUMAN VASCULAR ENDOTHELIUM AND SMOOTH-MUSCLE, Peptides, 15(3), 1994, pp. 497-503
Citations number
28
Categorie Soggetti
Biology
Journal title
Peptides → ACNP
ISSN journal
01969781
Volume
15
Issue
3
Year of publication
1994
Pages
497 - 503
Database
ISI
SICI code
0196-9781(1994)15:3<497:MOSANB>2.0.ZU;2-3
Abstract
Analysis of SP and NKA metabolism by human vascular endothelium, relat ive to that in human plasma, identified integrative, multiple pathways for the processing of circulating SP (but not NKA) by angiotensin-con verting enzyme (ACE; EC 3.4.15.1), dipeptidyl(amino)peptidase IV (DAP IV; EC 3.4.14.5), and aminopeptidase M (AmM; EC 3.4.11.2). In contrast , SP and NKA, which may diffuse into or be neurally released within th e vessel wall, were both metabolized by smooth muscle neutral endopept idase-24.11 (NEP-24.11; EC 3.4.24.11). Collectively, these studies ind icate peptide-specific and site-specific differential processing of SP and NKA by human plasma and vasculature.