The effect of different spatial-encoding (k-space) sampling distributi
ons are evaluated for magnetic resonance spectroscopic imaging (MRSI)
using Fourier reconstruction. Previously, most MRSI studies have used
square or cubic k-space functions, symmetrically distributed. These st
udies examine the conventional k-space distribution with spherical dis
tribution, and 1/2 k-space acquisition, using computer simulation stud
ies of the MRSI acquisition for three spatial dimensions and experimen
tal results. Results compare the spatial response function, Gibbs ring
ing effects, and signal contamination for different spatial-encoding d
istribution functions. Results indicate that spherical encoding, in co
mparison with cubic encoding, results in a modest improvement of the r
esponse function with approximately equivalent spatial resolution for
the same acquisition time. For spin-echo acquired data, reduced acquis
ition times can readily be obtained using 1/2 k-space methods, with a
concomitant reduction in signal to noise ratio.