PREDICTIVE ABILITY OF CREATININE CLEARANCE ESTIMATE MODELS IN PEDIATRIC BONE-MARROW TRANSPLANT PATIENTS

The predictive performance of estimating creatinine clearance (CrCl) w ith pediatric clearance models was evaluated, Thirty-two pediatric pat ients with stable renal function between the ages of 1 and 14 years ab out to undergo bone marrow transplantation (BMT) who had 12-24 h urine collections for measurement of CrCl were studied, The measured CrCl w as compared to CrCls calculated from seven models used to estimate CrC l in the pediatric population, The models used were Traub and Johnson, Schwartz et al, Counahan et al, modified Counahan ef al, Ghazali and Barratt, Shull ef al and Dechaux ef al, Coefficients of determination (r(2)) between measured and estimated CrCls from models 1 to 7 were 0. 47, 0.47, 0.47, 0.49, 0.47, 0.52, 0.47, The mean absolute percent erro rs for the models were 23.2-45.2%, In the majority of children, models overestimated CrCl, The tested models did not accurately predict CrCl and did not provide a reliable alternative to measured CrCl.