MOLECULAR-GENETIC HAPLOTYPE SEGREGATION STUDIES IN 3 FAMILIES WITH X-LINKED LYMPHOPROLIFERATIVE DISEASE

Authors
SCHUSTER V SEIDENSPINNER S GRIMM T KRESS W ZIELEN S BOCK M KRETH HW
Citation
V. Schuster et al., MOLECULAR-GENETIC HAPLOTYPE SEGREGATION STUDIES IN 3 FAMILIES WITH X-LINKED LYMPHOPROLIFERATIVE DISEASE, European journal of pediatrics, 153(6), 1994, pp. 432-437
Citations number
41
Categorie Soggetti
Pediatrics
Journal title
European journal of pediatrics → ACNP
ISSN journal
03406199
Volume
153
Issue
6
Year of publication
1994
Pages
432 - 437
Database
ISI
SICI code
0340-6199(1994)153:6<432:MHSSI3>2.0.ZU;2-8
Abstract
Three families with X-linked lymphoproliferative disease were studied. Affected males clinically presented with severe or fatal infectious m ononucleosis, acquired hy pogammaglobulinaemia, hypergammaglobulinaemi a M, and malignant lymphoma including Hodgkin disease. Haplotype analy sis using various DNA markers from Xq25-q27 allowed the prediction of the carrier status in females and identification of the XLP status in asymptomatic males.