HYALINIZATION AND CELLULAR-CHANGES IN UTERINE LEIOMYOMATA AFTER GONADOTROPIN-RELEASING-HORMONE AGONIST THERAPY

This study evaluated the microscopic changes in leiomyomata following the use of a gonadotropin releasing hormone (GnRH) agonist. Seventeen women with symptomatic leiomyomata were included. Nine were treated wi th a GnRH agonist for three to six months prior to surgery, and the re maining eight served as controls. Following myomectomy, paraffin secti ons were prepared from the tumors. These sections were examined micros copically by two gynecologic pathologists, who were blind to the patie nt groups. The results showed increased cellularity and hyalinization in leiomyomata following GnRH agonist treatment.