Gh. Eltabbakh et al., PRIMARY SYPHILIS AND NONIMMUNE FETAL HYDROPS IN A PENICILLIN-ALLERGICWOMAN - A CASE-REPORT, Journal of reproductive medicine, 39(5), 1994, pp. 412-414
The incidence of congenital syphilis is on the rise. Penicillin contin
ues to be the drug of choice for it during pregnancy. A penicillin-all
ergic woman with primary stage syphilis who was treated initially with
erythromycin presented with fever and nonimmune fetal hydrops seconda
ry to an intrauterine syphilitic infection. Following desensitization
and penicillin therapy the fetal hydrops disappeared, the pregnancy co
ntinued to term, and the patient delivered a small-for-gestational-age
but otherwise normal infant who continued to do well up to 1 year of
age.