Je. Brinchmann et al., EXPRESSION OF COSTIMULATORY MOLECULE CD28 ON T-CELLS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - FUNCTIONAL AND CLINICAL CORRELATIONS, The Journal of infectious diseases, 169(4), 1994, pp. 730-738
To study the functional integrity of T cells from human immunodeficien
cy virus type 1 (HIV-1)-infected persons, CD4(+) and CD8(+) cells were
examined for proliferation and secretion of interleukin-2 (IL-2) in r
esponse to staphylococcal superantigens and antibodies to CD3 and the
alpha beta T cell receptor. A functional defect within CD8(+) but not
within CD4(+) cells from HIV-1-infected persons was observed. Within C
D8(+) cells, proliferation and secretion of IL-2 was restricted to cel
ls expressing the costimulatory molecule CD28. Such cells were proport
ionally reduced in HIV-1-infected persons. In patients with advanced i
mmunodeficiency, however, evidence of functional derangement was found
also within the CD28(+) CD8(+) cells. In a cross-sectional study of 7
3 HIV-infected persons and 15 controls, a significant correlation was
observed between the number of CD28(+) CD8(+) cells and the presence o
f HIV-related disease. Our results suggest that regulation of expressi
on of CD28 may play an important role in the immunopathogenesis of AID
S.