EFFECTS OF DIFFERENT WEIGHT-LOSS TREATMENTS ON WEIGHT CYCLING AND METABOLIC MEASURES IN MALE-MICE

The effects of different weight loss treatments on subsequent weight r egain, food efficiency, body composition, metabolic rate, and corticos terone concentrations were investigated in obese male B6D2F(1) mice. T reatment groups were: restricted (RES, food restricted); exercised (EX , treadmill exercised); sham control (SHAM, treadmill exposure, not ex ercised); lab chow control (LC). Weight loss, regardless of treatment, resulted in increased rate of weight regain and food efficiency. Ther e were significant alterations in body composition after a cycle of we ight gain/loss. These results demonstrate that a cycle of weight gain/ loss causes increased food efficiency and concomitant alterations in b ody composition in male mice.