Ry. Calne et al., TOLERANCE OF PORCINE RENAL-ALLOGRAFTS INDUCED BY DONOR SPLEEN-CELLS AND 7 DAYS TREATMENT WITH CYCLOSPORINE, Transplantation, 57(10), 1994, pp. 1433-1435
Liver allografts in pigs and in rats elicit a substantial cellular imm
une response that can resolve spontaneously with the induction of dono
r-specific systemic tolerance. Self-limiting interactions between host
and donor (graft)-derived leukocytes may be the basis for tolerogenes
is. We have attempted to reproduce this effect of liver grafting in pi
gs by peroperative infusion of donor leukocytes into kidney graft reci
pients given an interrupted short course of CsA designed to promote do
nor leukocyte survival and interaction with host cells. This protocol
can secure long-term kidney graft survival resistant to challenge by d
onor skin grafting. Donor skin is, however, rejected, but more slowly
than third-party skin, indicating a degree of systemic specific unresp
onsiveness in these long-term kidney graft recipients.