A. Bishara et al., PREDICTION BY A MODIFIED MIXED LEUKOCYTE REACTION ASSAY OF GRAFT-VERSUS-HOST DISEASE AND GRAFT-REJECTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION, Transplantation, 57(10), 1994, pp. 1474-1479
In this report we describe a modified, sensitive MLR test that appears
to detect fine antigenic disparities between HLA-identical siblings c
onfirmed as such by serology and the standard MLR test, In a group of
40 consecutive allogeneic bone marrow transplants, reactivity detected
by the modified MLR test correlated with the development of rejection
of matched marrow grafts and onset of acute graft vs. host disease (a
GVHD). Thus, 13/15 positively reacting patient/donor pairs developed o
ne of these complications (P<0.001), while only 2/25 developed aGVHD i
n the negatively reacting group. This test may be useful for selecting
the most compatible donor when several potential donors are available
.