3-BETA,14-BETA-DIHYDROXY-13-ALPHA-ISOPROPYLABIETIC ACID, AN ELICITOR OF CONTACT ALLERGY

Authors
KHAN L SAEED MA
Citation
L. Khan et Ma. Saeed, 3-BETA,14-BETA-DIHYDROXY-13-ALPHA-ISOPROPYLABIETIC ACID, AN ELICITOR OF CONTACT ALLERGY, Journal of pharmaceutical sciences, 83(6), 1994, pp. 909-910
Citations number
16
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
83
Issue
6
Year of publication
1994
Pages
909 - 910
Database
ISI
SICI code
0022-3549(1994)83:6<909:3AAEO>2.0.ZU;2-X
Abstract
Abietic acid isolated from colophony (W.W. grade) was selectively oxid ized in the presence of KMnO4, into 13 beta,14 beta-dihydroxy-14 alpha -isopropylabietic acid. The structure of the compound was elucidated u sing UV, IR, and NMR spectroscopy. Epicutaneous application of the dih ydroxy acid to colophony-sensitized guinea pigs suggested the compound as an elicitor of contact allergy that had not been tested before in contact-sensitization reactions.