SELECTIVE ELECTROCHEMICAL FORMYL HYDROGEN-EXCHANGE FLUORINATION OF ALIPHATIC-ALDEHYDES TO PREPARE ACYL FLUORIDES USING HF-BASE SOLUTIONS

The selective displacement of formyl hydrogen (-(C=O)-H) to fluorine i n aliphatic aldehydes was successfully carried out electrochemically t o give acyl fluorides in base-nHF (base: pyridine or Et(3)N, n=3-6) el ectrolyte solution with or without solvents such as acetonitrile and s ulfolane.