A COMBINED HEPATOCELLULAR CHOLANGIOCELLULAR CARCINOMA WITH SARCOMATOID FEATURES/

Citation
M. Papotti et al., A COMBINED HEPATOCELLULAR CHOLANGIOCELLULAR CARCINOMA WITH SARCOMATOID FEATURES/, Liver, 17(1), 1997, pp. 47-52
Citations number
17
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
LiverACNP
ISSN journal
01069543
Volume
17
Issue
1
Year of publication
1997
Pages
47 - 52
Database
ISI
SICI code
0106-9543(1997)17:1<47:ACHCCW>2.0.ZU;2-I
Abstract
A case of primary liver cancer showing combined hepatocellular and cho langiocellular features and an associated pseudosarcomatous (schwannom atous) component is presented. Histologically, compact microtrabecular and glandular patterns in a dense fibrous stroma were recognized. The latter showed transition towards spindle cell sarcomatous growth in s everal areas of both the primary and the lymph-node metastasis. Glandu lar areas expressed acidic mucins and AE1-reactive keratins; albumin m RNA was detected by in situ hybridization in both trabecular and gland ular areas. Vimentin and S-100 protein were mostly expressed in the ps eudosarcomatous areas. Both the morphological patterns and the phenoty pic features indicate that divergent differentiation along both epithe lial and mesenchymal lineages took place in this rare primary liver tu mor.