Jl. Boyer et al., G-PROTEIN-MEDIATED REGULATION OF PHOSPHOLIPASE-C - INVOLVEMENT OF BETA-GAMMA-SUBUNITS, Trends in cardiovascular medicine, 4(2), 1994, pp. 88-95
The protein components of the G-protein-linked cell surface receptor-r
egulated inositol lipid-signaling cascade have been identified recentl
y. The G(q) family of G-protein alpha subunits is responsible for pert
ussis toxin-insensitive activation of a family of phospholipase C-beta
isoenzymes. However, it also has been shown that G-protein betagamma
subunits activate certain of these phospholipase C-beta isoenzymes, an
d that this novel activity may account for activation of phospholipase
C by G proteins that are not members of the G(q) family, including th
ose that account for pertussis-toxin-sensitive inositol lipid signalin
g.