CYCLOPENTAANNULATION OF PODOCARPIC ACID-DERIVATIVES VIA (ETA-6-ARENE)TRICARBONYLCHROMIUM(0) COMPLEXES - RING-D MODIFICATION

Authors
CAMBIE RC RUTLEDGE PS STEVENSON RJ WOODGATE PD
Citation
Rc. Cambie et al., CYCLOPENTAANNULATION OF PODOCARPIC ACID-DERIVATIVES VIA (ETA-6-ARENE)TRICARBONYLCHROMIUM(0) COMPLEXES - RING-D MODIFICATION, Journal of organometallic chemistry, 471(1-2), 1994, pp. 133-147
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of organometallic chemistry → ACNP
ISSN journal
0022328X
Volume
471
Issue
1-2
Year of publication
1994
Pages
133 - 147
Database
ISI
SICI code
0022-328X(1994)471:1-2<133:COPAV(>2.0.ZU;2-R
Abstract
Functionalization of the (eta6-arene)tricarbonylchromium(0) complexes of some podocarpic acid (1) derivatives has been achieved via addition -oxidation methodology. The resulting decomplexed products underwent L ewis acid-mediated cyclopentaannulation to give ring-C aromatic andros tane analogues in high yield. The D rings of these steroidal analogues were modified by both oxidation and reduction sequences, becoming str ucturally similar to some of the C15- or C17-oxygenated naturally occu rring steroids.