ASSOCIATION BETWEEN CELL-MEMBRANE POTENTIAL AND BREAST-CANCER

Cell membrane potentials were measured in breast tissue and in breast epithelial cells to explore the relation between cell membrane potenti als, oncogenesis and electrical potentials previously measured on the surface of the breast. The mean membrane potential in breast biopsy ti ssue from 9 women with infiltrating ductal carcinoma was significantly depolarized, compared with values measured in tissue from 8 women wit h benign breast disease. Depolarization was also observed in transform ed breast epithelial cells, compared with normal breast cells; the tra nsformed cells were particularly sensitive to the action of K+ channel blockers. The results were consistent with previous observations of e lectropositivity of skin sites over malignant tumors of the breast.