SEQUENCE-SPECIFIC CLEAVAGE OF YEAST TRNA(PHE) WITH OLIGONUCLEOTIDES CONJUGATED TO A DIIMIDAZOLE CONSTRUCT

Authors
VLASSOV V ABRAMOVA T GODOVIKOVA T GIEGE R SILNIKOV V
Citation
V. Vlassov et al., SEQUENCE-SPECIFIC CLEAVAGE OF YEAST TRNA(PHE) WITH OLIGONUCLEOTIDES CONJUGATED TO A DIIMIDAZOLE CONSTRUCT, ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 7(1), 1997, pp. 39-42
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental","Biothechnology & Applied Migrobiology
Journal title
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT → ACNP
ISSN journal
10872906
Volume
7
Issue
1
Year of publication
1997
Pages
39 - 42
Database
ISI
SICI code
1087-2906(1997)7:1<39:SCOYTW>2.0.ZU;2-2
Abstract
Oligonucleotide derivatives conjugated to a chemical construction,vith two histamine residues imitating the catalytic center of ribonuclease A have been synthesized. In experiments with the conjugates complemen tary to the 3'-end and to the variable loop and the T loop of yeast tR NA(Phe), if was shown that the compounds can accomplish sequence-speci fic cleavage of the target RNA in physiologic conditions.