ARGENTEANONES-C-E AND ARGENTEANOLS-B-E, CYTOTOXIC CYCLOARTANES FROM AGLAIA-ARGENTEA

Authors
MOHAMAD K MARTIN MT LEROY E TEMPETE C SEVENET T AWANG K PAIS M
Citation
K. Mohamad et al., ARGENTEANONES-C-E AND ARGENTEANOLS-B-E, CYTOTOXIC CYCLOARTANES FROM AGLAIA-ARGENTEA, Journal of natural products, 60(2), 1997, pp. 81-85
Citations number
10
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
2
Year of publication
1997
Pages
81 - 85
Database
ISI
SICI code
0163-3864(1997)60:2<81:AAACCF>2.0.ZU;2-T
Abstract
Seven new cycloartanes, argenteanones C-E (4-6) and argenteanols B-E ( 7-10), have been isolated from Aglaia argentea leaves. All of these co mpounds possess significant cytotoxic activity against KB cells (IC50 values between 3.7 and 6.2 mu g/mL). Structure elucidation was perform ed by 2D NMR spectroscopy, aided by molecular modeling in the case of the side chain of compound 7.