QUANTITATIVE-DETERMINATION OF DRUG COUNTERION STOICHIOMETRY BY CAPILLARY ELECTROPHORESIS

CE has been shown to be a useful technique for the quantitative determ ination of common drug counterions. Data generated by CE compares well with theoretical ion contents, microanalysis and ion chromatography d ata. Acceptable method performance in terms of linearity, accuracy, pr ecision of peak areas and migration times for the CE methods are demon strated. An internal standard was shown to improve injection precision . Given their speed, simplicity and robustness, the CE methods describ ed are now in routine use for batch release of selected drug substance material.