ANTINEOPLASTIC AGENTS .362. ISOLATION AND X-RAY CRYSTAL-STRUCTURE OF DIBROMOPHAKELLSTATIN FROM THE INDIAN-OCEAN SPONGE PHAKELLIA-MAURITIANA

Authors
PETTIT GR MCNULTY J HERALD DL DOUBEK DL CHAPUIS JC SCHMIDT JM TACKETT LP BOYD MR
Citation
Gr. Pettit et al., ANTINEOPLASTIC AGENTS .362. ISOLATION AND X-RAY CRYSTAL-STRUCTURE OF DIBROMOPHAKELLSTATIN FROM THE INDIAN-OCEAN SPONGE PHAKELLIA-MAURITIANA, Journal of natural products, 60(2), 1997, pp. 180-183
Citations number
42
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
2
Year of publication
1997
Pages
180 - 183
Database
ISI
SICI code
0163-3864(1997)60:2<180:AA.IAX>2.0.ZU;2-#
Abstract
Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychell es sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity ha ve been summarized. P. mauritiana was also found to contain dibromopha kellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thy mine.