COMBINATION CHEMOTHERAPY FOR MALIGNANT PARAGANGLIOMA

Treatment with a combination chemotherapeutic regimen consisting of cy clophosphamide, vincristine, and dacarbazine for malignant paraganglio ma with hepatic metastasis is reported, A 51-year-old male presented w ith tumors in the retroperitoneal space and liver, The patient was dia gnosed as having paraganglioma based on elevated levels of serum neuro n-specific enolase, urinary catecholamine and vanillylmandelic acid, a nd on histological findings of the liver specimen, The patient was tre ated with this combination chemotherapy in repeated 21-day cycles, Tem porary improvement in laboratory findings and a 20% reduction in the s ize of the hepatic masses were observed without severe adverse effects .