CHURG-STRAUSS-SYNDROME ASSOCIATED WITH NECROTIZING CRESCENTIC GLOMERULONEPHRITIS IN A DIABETIC PATIENT

We report a patient with Churg-Strauss syndrome-associated rapidly pro gressive glomerulonephritis concurrent with diabetes mellitus. The pat ient was a 64-year-old woman who was admitted to our hospital because of a glove and stocking type hypesthesia and numbness, multiple purpur ae on both legs, and renal insufficiency with hematuria and proteinuri a. Renal biopsy revealed necrotizing crescentic glomerulonephritis acc ompanied by necrotizing arteritis, marked eosinophilic infiltration of the interstitium, and diffuse and nodular diabetic glomerulosclerosis . Cyclophosphamide and steroid therapy succeeded in improving her neur ologic symptoms as well as retarding the deterioration in renal functi on, No clinical manifestations suggestive of a recurrence of Churg-Str auss syndrome have been observed during the one-year follow-up period.