NOVEL PATTERNS OF P53 ABNORMALITY IN BREAST-CANCER FROM TAIWAN - EXPERIENCE FROM A LOW-INCIDENCE AREA

Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22 .8%) and p53 accumulation (38.3%) was similar to that in high-incidenc e areas. However, novel patterns of p53 abnormalities, including uniqu e sites or types of mutation (i.e. an excessive proportion of G:C to A :T transition at CpG site), and accumulation of wild-type p53 either w ithin nuclear or cytoplasmic compartments were noted. These may have r elevance to breast cancer in Taiwan, a low-incidence area.