SIGNIFICANCE OF ORAL EXAMINATION IN CHRONIC GRAFT-VERSUS-HOST DISEASE

Fourteen patients who received allogeneic bone marrow transplantation (BMT) were examined 100 to 220 days after BMT. Ten out of 14 patients were diagnosed as having chronic graft-versus-host disease (cGVHD) in skin, liver, eyes and other organs. These cGVHD patients also had obje ctive evidence of oral involvement. Subjective xerostomia was experien ced by 7 cGVHD patients and decreased whole saliva flow was observed i n 4 cGVHD patients. However, no patient had a history of parotid swell ing or notable abnormality in parotid sialography. Labial salivary gla nds (LSG) of 9 cGVHD patients showed atrophy and/or destruction in ass ociation with diffusely infiltrating lymphocytes. The infiltrating lym phocytes were mainly CD3(+) T cells with a predominance of CD8(divided by) cells over CD4(+) cells. Lichenoid lesions on the oral mucosa wer e also observed in 5 cGVHD patients. Thus, this study indicated that o ral examination, including LSG biopsy, is useful in the diagnosis of c GVHD.