ELECTRORETINOGRAPHIC EFFECTS OF HALOPERIDOL ON THE MOUSE RETINA

The effects of haloperidol on the electroretinogram were studied in mi ce injected intraperitoneally with haloperidol. A dose-related study w as performed. A significant decrease in the amplitude of the b-wave wa s found in the mice injected with more than 20 mg/kg of haloperidol. H owever, the peak latency of the b-wave and the stimulus intensity requ ired to elicit a b-wave of one half of the maximum b-wave amplitude re mained unchanged. No significant changes were found in the a-wave. Thi s change in the electroretinogram recovered 24 hours after the injecti on. These results suggest that functional change occurred at the retin al level after intraperitoneal injection