TREATMENT OF CANDIDAL VULVO-VAGINITIS WIT H A SINGLE DIFLUCAN DOSE

A single oral intake of a diflucan capsule containing 150 mg of the dr ug was used to treat candidal vulvovaginitis in 53 patients. The diagn osis was mycologically confirmed in all the cases. Total immediate eff icacy (1-2 weeks after drug intake) was 84.9 %, that after intake of t he second capsule (in cases when the first one was ineffective) 92.45 %. The efficacy of therapy for vulvovaginitis caused by C. albicans de pended on the degree of initial colonization of the vagina with the fu ngi: primary therapy was ineffective in all the cases with high coloni zation degree (10(5-7) CFU/tampone), and only after second dose the ag ent was eliminated in all the patients. Therapy of vulvovaginitis caus ed by C. stellatoidea or T. glabrata was ineffective even when the vag ina was moderately colonized (10(3-4) CFU/tampone).