CURATIVE EFFECTS ON RAT SARCOMAS OBTAINED AFTER A TREATMENT COMBINING2 MONOCLONAL-ANTIBODIES

The effects of a treatment involving two monoclonal antibodies (Ab) we re evaluated on benzo(a)pyrene [B(a)P]-induced malignant sarcomas in S prague-Dawley female rats. These Ab were, respectively, an anti-anti-c onjugated B(a)P AB, an internal image of conjugated B(a)P, called AIB1 , and an anti-conjugated L-DOPA Ab. They were biweekly injected into a nimals with small clinically palpable tumors. Anti-'phosphatidylinosit ol-like' autoantibody (autoAb) levels which were significantly higher in B(a)P-treated rat sera were decreased after Ab treatment. Tumor gro wth was slowed down compared with that of controls and animal survival was increased. This treatment was more efficient than that involving AIB1 alone. The anti-conjugated L-DOPA Ab may play a role in neovascul arization, which is known to be critical for tumor growth.